Pharmacological Therapy Determines the Gut Microbiota Modulation by a Pomegranate Extract Nutraceutical in Metabolic Syndrome: A Randomized Clinical Trial
نویسندگان
چکیده
Scope Poly-pharmacological therapy shapes the gut microbiota (GM) in metabolic syndrome (MetS) patients. The effects of polyphenols poly-medicated MetS patients are unknown. Methods and results A randomized, placebo-controlled, double-blinded, crossover trial (n=50) explored whether a pomegranate extract nutraceutical (PE, 320 mg phenolics/day for 1 month) affected by drug therapy. Considering lipid-lowering (LL-), anti-hypertensive (HP-) and(or) anti-diabetic (AD-) treatments: GM (16S rRNA sequencing), short-chain fatty acids, 40 inflammatory-metabolic endotoxemia-related biomarkers, associations between biomarkers with 53 cardiometabolic dysfunctions-related single-nucleotide polymorphisms (SNPs), urolithin metabotypes (UMs) influence evaluated. Representative SNPs-GM after PE include Lactococcus ClostridiumXIVa rs5443-GNB3 (G-protein-?-polypeptide-3) rs7903146-TCF7L2 (transcription-factor-7-like-2) rs1137101-LEPR (leptin-receptor). decreases sICAM-1 LL-patients lipopolysaccharide-binding protein all does not affect other patients’ markers as group or stratifying UMs. After PE, increases AD-, LL-, HP-patients, Bifidobacterium LL- while Clostridium XIVa non-LL- non-HP-patients. Conclusion prebiotic effect depends on medication, mainly HP-treatments. Targeting can complement therapy, but should be considered individually.
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ژورنال
عنوان ژورنال: Molecular Nutrition & Food Research
سال: 2021
ISSN: ['1613-4125', '1613-4133']
DOI: https://doi.org/10.1002/mnfr.202001048